Study of the excretion in bile and concentration in the gall bladder wall of rifamide.

EDITORIAL COMMENT Studies have been made of the biliary excretion of the antibiotic rifamide in patients with T-tube drainage of the bile ducts. Using a therapeutic dose, the concentration achieved is 100,000 times the minimal inhibitory concentration for Gram-positive and about 100 times that for Gram-negative micro-organisms. Concentrations in the gall bladder were less but were of therapeutic value, particularly with Gram-positive organisms.